Oxford University, Structural Bioinformatics & Computational Biochemistry Unit

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Chen Song

EC Marie Curie Research Fellow Dept. of Biochemistry University of Oxford South Parks Road Oxford OX1 3QU U.K. Telephone: 01865 613304 Fax: 01865 613238 e-mail: chen.song@bioch.ox.ac.uk

The functional mechanisms of antimicrobial peptides and ion channels
Background
BSc: Physics, Shandong University, China, 2002 PhD: Physics, Shandong University, China, 2007 2007-2009, postdoc research associate in the group of Dr. Ben Corry, University of Western Australia 2009-2012, Humboldt postdoc research fellow in the group of Prof. Bert L. de Groot, Max Planck Institute for Biophysical Chemistry.
Research
I am interested in theoretical and computational studies on membrane proteins such as antimicrobial peptides and ion channel. Currently, I am working on antimicrobial peptide Dermcidin and ion channel KcsA. My study is supported by a Marie Curie Intra European Fellowship within the 7th European Community Framework Programme.
Recent Publications
[1] David A. Koepfer, Chen Song, Tim Gruene, George M. Sheldrick, Ulrich Zachariae, Bert L. de Groot. Ion permeation in K⁺ channels occurs by direct Coulomb knock-on. Science, 346:352-355, 2014. (co-first author and shared corresponding author) [2] Chen Song, Conrad Weichbrodt, Evgeniy S. Salnikov, Marek Dynowski, Bjoern O. Forsberg, Burkhard Bechinger, Claudia Steinem, Bert L. de Groot, Ulrich Zachariae and Kornelius Zeth. Crystal structure and functional mechanism of a human antimicrobial membrane channel. Proc. Natl. Acad. Sci. USA, 110:4586-4691, 2013. [3] Chen Song and Ben Corry. Testing the applicability of Nernst-Planck theory in ion channels: Comparisons with Brownian dynamics simulations PLoS ONE, 6:e21204, 2011. [4] Chen Song and Ben Corry. Ion conduction in ligand-gated ion channels: Brownian dynamics studies of four recent crystal structures. Biophys. J., 98:404-411, 2010. [5] Chen Song and Ben Corry. An intrinsic ion selectivity of narrow hydrophobic pores. J. Phys. Chem. B, 113:7642-7649, 2009.

Last updated 23/10/14