Dr Antreas C. Kalli

Investigation of membrane and peripheral proteins involved in signal transduction

Research

My research is focused on the investigation of biologically significant membrane and peripheral proteins involved in signal transduction pathways with the use of computational and experimental approaches

My research is funded by the Wellcome Trust.

Publications

Kalli, A.C., et al., The Structure of the Talin/Integrin Complex at a Lipid Bilayer: An NMR and MD Simulation Study. Structure, 2010. 18(10): p. 1280-1288.

Kalli, A.C., I.D. Campbell, and M.S.P. Sansom, Multiscale simulations suggest a mechanism for integrin inside-out activation. Proceedings of the National Academy of Sciences, 2011. 108(29): p. 11890-11895.

Kalli, A.C., et al., A Helix Heterodimer in a Lipid Bilayer: Prediction of the Structure of an Integrin Transmembrane Domain via Multiscale Simulations. Structure, 2011. 19(10): p. 1477-1484.

Kalli, A.C., et al., Interactions of the Auxilin-1 PTEN-like Domain with Model Membranes Result in nanoclustering of Phosphatidyl Inositol Phosphates. Biophysical Journal, 2013 105(1):137-145.

Kalli, A.C., I.D. Campbell and M.S.P. Sansom, Conformational Changes in Talin on Binding to Anionic Phospholipid Membranes Facilitate Signalling by Integrin Transmembrane Helices. PLOS Comput. Biol., 2013 9(10):e1003316.

Kalli, A.C., et al., Interactions of PTEN Proteins with Phosphatidyl Inositol Phosphates: Insights from Molecular Dynamics Simulations of PTEN and VSP. Biochemistry, 2014. 53(11), 1724-1732.

Kalli, A.C., and M.S.P. Sansom, Interactions of Peripheral Proteins with Model Membranes as Viewed by Molecular Dynamics Simulations. Biochem. Soc. Trans., 2014 (42), 1418-1424