Oxford University, Structural Bioinformatics & Computational Biochemistry Unit
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Dr Maria Musgaard

Structural Bioinformatics and Computational Biochemistry Unit
Dept. of Biochemistry
University of Oxford
South Parks Road

Telephone: 01865 613304
Fax: 01865 613238

e-mail: maria.musgaard@bioch.ox.ac.uk

division line

Molecular dynamics simulations of glutamate receptors


I obtained my BSc, MSc and PhD degrees in Medicinal Chemistry from Aarhus University, Aarhus, Denmark. My PhD research focused mainly on molecular dynamics simulations of the calcium ATPase from sarco(endo)plasmic reticulum, SERCA, in close collaboration with the crystallography group at the PUMPkin research centre.


My current research focuses on receptor dynamics with a particular emphasis on the ionotropic glutamate receptors. We are especially seeking to describe how the ion channel opens, and how this event is coupled to the preceding ligand binding.
The work is supported by the Leverhulme Trust.


*Equal contributions

Defining the structural relationship between kainate-receptor deactivation and desensitization
Dawe, G. B.*; Musgaard, M.*; Andrews, E. D.; Daniels, B. A.; Aurousseau, M. R. P.; Biggin, P. C.; Bowie, D.
Nature Structure & Molecular Biology (2013) 20, 1054-1061. DOI: 10.1038/nsmb.2654 Link

The dynamics of camphor in the cytochrome P450 CYP101D2
Vohra, S.; Musgaard, M.; Bell, S. G.; Wong, L.-L.; Zhou, W.; Biggin, P. C.
Protein Science (2013) 22, 1218-1229. DOI: 10.1002/pro.2309 Link

Ion pathways in the Sarcoplasmic Reticulum Ca2+-ATPase
Bublitz, M.; Musgaard, M.; Poulsen, H.; Thøgersen, L.; Olesen, C.; Schiøtt, B.; Morth, J. P.; Møller, J. V.; Nissen, P.
The Journal of Biological Chemistry (2013) 288, 10759-10765. DOI: 10.1074/jbc.R112.436550 Link

Tracing cytoplasmic Ca2+ ion and water access points in the Ca2+-ATPase
Musgaard, M.; Thøgersen, L.; Schiøtt, B.; Tajkhorshid, E.
Biophysical Journal (2012) 102, 268-277. DOI: 10.1016/j.bpj.2011.12.00 Link

On the protonation states of important acidic residues in the central Ca2+ ion binding sites of the Ca2+-ATPase - a molecular modeling study
Musgaard, M.; Thøgersen, L.; Schiøtt, B.
Biochemistry (2011) 50, 11109-11120. DOI: 10.1021/bi201164b Link

Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes
Sonntag, Y.*; Musgaard, M.*; Olesen, C.; Schiøtt, B.; Møller, J. V.; Nissen, P.; Thøgersen, L.
Nature Communications (2011) 2, 304. DOI: 10.1038/ncomms1307 Link

Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter
Sinning, S.*; Musgaard, M.*; Jensen, M.*; Severinsen, K.*; Celik, L.*; Koldsø, K.*; Meyer, T.; Bols, M.; Jensen, H. H.; Schiøtt, B.; Wiborg, O.
The Journal of Biological Chemistry (2010) 285, 8363-8374. DOI: 10.1074/jbc.M109.045401 Link

P-type ATPases as drug targets: Tools for medicine and science
Yatime, L.; Buch-Pedersen, M. J.; Musgaard, M.; Morth, J. P.; Winther, A.-M. L.; Pedersen, B. P.; Olesen, C.; Andersen, J. P.; Vilsen, B.; Schiøtt, B.; Palmgren, M. G.; Møller, J. V.; Nissen, P.; Fedosova, N.
Biochimica et Biophysica Acta - Bioenergetics (2009) 1787, 207-220. DOI: 10.1016/j.bbabio.2008.12.019 Link
Last updated 6 Mar 2012