Sarah-Beth T. A. Amos

Background

I completed my undergraduate degree in Biochemistry at King's College, London, graduating in 2014. Consequently I was awarded an MRC Studentship to undertake an MRes in Molecular Biophysics, also at King's, where I carried out a molecular dynamics project investigating mechanisms of action of antimicrobial peptides. Currently I am a 3rd year DPhil student at Wadham College. I am funded by a BBSRC CASE studentship in partnership with UCB.

Research

My current work is on MD simulations of peripheral membrane proteins and their interactions with lipid membranes. I am also interested in Markov state modelling of disordered proteins and mathematical modelling of signalling events.

Publications

Sarah-Beth T. A. Amos, Louic S. Vermeer, Philip M. Ferguson, Justyna Kozlowska, Matthew Davy, Tam T. Bui, Alex F. Drake, Christian D. Lorenz, A. James Mason (2016) Antimicrobial Peptide Potency is Facilitated by Greater Conformational Flexibility when Binding to Gram-negative Bacterial Inner Membranes. Scientific Reports(6): e37639. doi:10.1038/srep37639

Justyna Kozlowska, Louic S. Vermeer, Geraint B. Rogers, Nabila Rehnnuma, Sarah-Beth T. A. Amos, Garrit Koller, Michael McArthur, Kenneth D. Bruce, A. James Mason. (2014) Combined Systems Approaches Reveal Highly Plastic Responses to Antimicrobial Peptide Challenge in Escherichia coli. PLoS Pathog 10(5): e1004104. doi:10.1371/journal.ppat.1004104