Members of the Laboratory - Teresa Paramo
I graduated in Computer Science from the University of Valladolid, following on to obtain a MSci in Bioinformatics from the University Pompeu i Fabra/University of Barcelona. After a brief experience in industry, I headed back to academia to pursue a Ph.D. in Computational Chemistry at the University of Cambridge, where I graduated in 2014. My Ph.D. research involved the application and development of computational approaches towards the characterisation of the allosteric regulation of the TLR4 protein in response to endotoxin.
Currently, I am exploring the kainate receptor pharmacology by using a range of computational methodologies, including molecular modelling, docking, alchemical free energy calculations and molecular dynamic (MD) simulations. Ultimately, the knowledge gained from this study may be used to design potent and selective modulators for this particular subgroup of glutamate receptors.
Paramo, T., East, A., Garzón, D., Ulmschneider, M. B., & Bond, P. J. (2014). Efficient characterization of protein cavities within molecular simulation trajectories: trj_cavity. Journal of Chemical Theory and Computation, 10(5), 2151-2164
Paramo, T., Piggot, T. J., Bryant, C. E., & Bond, P. J. (2013). The structural basis for endotoxin-induced allosteric regulation of the Toll-like receptor 4 (TLR4) innate immune receptor . Journal of Biological Chemistry, 288(51), 36215-36225.
Paramo, T., Garzón, D., Holdbrook, D. A., Khalid, S., & Bond, P. J. (2013). The Simulation Approach to Lipid–Protein Interactions. Humana Press, 435-455