Members of the Laboratory - Dr Maria Musgaard
BackgroundI obtained my BSc, MSc and PhD degrees in Medicinal Chemistry from Aarhus University, Aarhus, Denmark. My PhD research focused mainly on molecular dynamics simulations of the calcium ATPase from sarco(endo)plasmic reticulum, SERCA, in close collaboration with the crystallography group at the PUMPkin research centre.
ResearchMy current research focuses on receptor dynamics with a particular emphasis on the ionotropic glutamate receptors. We are especially seeking to describe how the ion channel opens, and how this event is coupled to the preceding ligand binding.The work is supported by the Leverhulme Trust. Publications*Equal contributions Defining the structural relationship between kainate-receptor deactivation and desensitization Dawe, G. B.*; Musgaard, M.*; Andrews, E. D.; Daniels, B. A.; Aurousseau, M. R. P.; Biggin, P. C.; Bowie, D. Nature Structure & Molecular Biology (2013) 20, 1054-1061. DOI: 10.1038/nsmb.2654 Link The dynamics of camphor in the cytochrome P450 CYP101D2 Vohra, S.; Musgaard, M.; Bell, S. G.; Wong, L.-L.; Zhou, W.; Biggin, P. C. Protein Science (2013) 22, 1218-1229. DOI: 10.1002/pro.2309 Link Ion Pathways in the Sarcoplasmic Reticulum Ca2+-ATPase Bublitz, M.; Musgaard, M.; Poulsen, H.; Thøgersen, L.; Olesen, C.; Schiøtt, B.; Morth, J. P.; Møller, J. V.; Nissen, P. The Journal of Biological Chemistry (2013) 288, 10759-10765. DOI: 10.1074/jbc.R112.436550 Link Tracing cytoplasmic Ca2+ ion and water access points in the Ca2+-ATPase Musgaard, M.; Thøgersen, L.; Schiøtt, B.; Tajkhorshid, E. Biophysical Journal (2012) 102, 268-277. DOI: 10.1016/j.bpj.2011.12.00 Link On the protonation states of important acidic residues in the central Ca2+ ion binding sites of the Ca2+-ATPase - a molecular modeling study Musgaard, M.; Thøgersen, L.; Schiøtt, B. Biochemistry (2011) 50, 11109-11120. DOI: 10.1021/bi201164b Link Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes Sonntag, Y.*; Musgaard, M.*; Olesen, C.; Schiøtt, B.; Møller, J. V.; Nissen, P.; Thøgersen, L. Nature Communications (2011) 2, 304. DOI: 10.1038/ncomms1307 Link Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter Sinning, S.*; Musgaard, M.*; Jensen, M.*; Severinsen, K.*; Celik, L.*; Koldsø, K.*; Meyer, T.; Bols, M.; Jensen, H. H.; Schiøtt, B.; Wiborg, O. The Journal of Biological Chemistry (2010) 285, 8363-8374. DOI: 10.1074/jbc.M109.045401 Link P-type ATPases as drug targets: Tools for medicine and science Yatime, L.; Buch-Pedersen, M. J.; Musgaard, M.; Morth, J. P.; Winther, A.-M. L.; Pedersen, B. P.; Olesen, C.; Andersen, J. P.; Vilsen, B.; Schiøtt, B.; Palmgren, M. G.; Møller, J. V.; Nissen, P.; Fedosova, N. Biochimica et Biophysica Acta - Bioenergetics (2009) 1787, 207-220. DOI: 10.1016/j.bbabio.2008.12.019 Link |