Biggin Group - Computational Biochemistry

Members of the Laboratory - Max Epstein


I obtained my BSc in Pharmacology from Bristol University. My Undergraduate research focused on the pharmacological characterisation of sunifiram and its analogues as part of David Jane's group. Using molecular modelling techniques, I helped design a number of AMPA receptor PAMs which I subsequently synthesised and tested using field EPSP recordings.


My current research focuses on the rational design of nAChR antagonists for the treatment of nerve agent exposure. I am interested in how molecular dynamics can be used to elucidate the binding modes of various bispyridinium ligands and how they can be optimised to improve their therapuetic efficacy.

The work is supported by the EPSRC and DSTL in the form of an industrial CASE studentship.