Members of the Laboratory - Laura Domicevica
I received my degree of BSc Human Genetics from Newcastle University in 2013. In October of 2013 I started my DPhil in Biochemistry in the Biggin group. I am also a graduate student at Lady Margaret Hall.
My project focuses on P-glycoprotein, the main cause in multi-drug resistance in cancer and efflux mechanism for many clinically important substrates, using molecular simulation methodologies to research the aspects of CNS-type drug interactions with P-glycoprotein and lipid bilayer. Investigation of how inhibitors and substrates are accessing P-glycoprotein can be of particular pharmaceutical importance, as it could help to understand why a specific drug will be effluxed by P-gp or transported over blood-brain-barrier. The research is supervised by Dr Phillip Biggin.
The research is funded by NC3Rs (National Centre for the Replacement, Refinement and Reduction of Animals in Research).
Domicevica, L., Biggin, P.C. (2015). Homology modelling of human P-glycoprotein Biochemical Society Transactions, 43(5),952-958
Ma, J. Domicevica, L. , Schnell, J.R & Biggin, P.C. (2015). Position and orientational preferences of drug-like compounds in lipid membranes: a computational and NMR approach Physical Chemistry Chemical Physics, 17, 19766-19776