publications

LIST OF PUBLICATIONS
1. Shang, L., Lucchese, C.J., Haider, S ., Sansom, M.S.P. and Tucker, S. (2005)
    Functional Characterisation of missense variations in the Kir4.1 potassium channel (KCNJ10) associated with seizure
    susceptibility.
    (In Press Molecular Brain Research)

2. Haider, S., Antcliff, J., Proks, P., Sansom, M.S.P. and Ashcroft, F. (2005).
    Focus on Kir6.2: A Key Component of the ATP-sensitive potassium channel
    (In Press Journal of Molecular and Cellular Cardiology)

3. Proks, P., Girard, C, Haider, S., Golyn, A., Hattersely, A. Sansom, M.S.P. and Ashcroft, F.M. (2005).
    A novel gating mutation at the internal mouth of the Kir6.2 pore associated with DEND syndrome
EMBO reports 6: 470-475

4. Haider, S., Grotessi, A., Ashcroft, F. and Sansom, M.S.P. (2005).
    Modelling and Simulation Studies of the Intracellular Domains of the Inwardly Rectifying K+ Channels.
    Biophysical Journal 88(5): 3310-3320

5. Grotessi, A., Domene, C., Haider, S ., and Sansom, M.S.P. (2005).
    Molecular Dynamics Simulation Approaches to K Channels: Conformational Flexibility to Physiological Functions
    IEEE transactions on Nanobioscience Vol. 4., No. 1., March 2005, 112-120

6. Antcliff, J., Haider, S*., Proks, P., Sansom, M.S.P. and Ashcroft, F. (2005).
    Functional Analysis of a structural model of the ATP -binding site of the KATP channel Kir6.2 subunit .
    EMBO. J . 24(2):229 -239

7. Harrison, J., Romangnoli, B., Morrell, J., Reszka, A., Haider, S., Gowan, S., Incles, C., Kelland, L. and Neidle, S. (20
    Acridone Derivatives for the Selective Inhibition of Telomerase
    Bioorg and Med. Chem Letters. 14: 5845- 5849

8. Trapp, S., Haider, S., Jones,P. Sansom, M.S.P. and Ashcroft, F. (2003).
    Identificat ion of residues contributing to the ATP-binding site of Kir 6.2.
    EMBO. J . 22(12):2903- 2912

9. Domene,C., Haider, S.* and Sansom, M.S.P. (2003)
    Ion Channel Structures: A Review of recent progress
    Current Opinion in Drug Discovery and Development. 6(5), 611- 61 9

10. Haider, S.M.S., Parkinson, G. and Neidle, S. (2003).
    Crystal Structure of the G-Quadruplex DNA -Drug complex.
    J. Mol. Biol. 326(1), 117- 125

11. Haider, S., Parkinson, G. and Neidle, S. (2002).
    Crystal structure of the potassium form of a Oxytricha nova G- Quadruplex
    J. Mol. Biol. 320(2), 189- 200

12. Haider, S.M.S., Parkinson, G., Read, M.A. and Neidle, S. (2002).
    Design and Analysis of G4 recognition compounds.
    Small Molecules DNA and RNA Binders:From Synthesis to Nucleic Acid Complexes
    Eds. M. Demeunynck, C.Bailly and D.Wilson ISBN: 3- 527- 30595 -5 pages 337 - 359; Publisher Wiley- VCH

13. Haider, S. and Ahmad, M. (2001)
    Incidence of multiple drug resistance in E.coli in riverine systems around Aligarh.
    Chem. Environ. Res. 10, 147- 154

* - joint first author for the work

PDB STRUCTURES
1. Haider, S.M.S., Parkinson, G. and Neidle, S. (2002).
    Crystal Structure of the G- Quadruplex DNA -Drug complex. PDB accession code 1L1H

2. Haider, S.M.S., Parkinson, G. and Neidle, S. (2001).
    Crystal structure of the oxytricha telomeric DNA at 1.6Å. PDB accession code 1JPQ

3. Haider, S.M.S., Parkinson, G. and Neidle, S. (2001).
    Orthorhombic form of oxytricha telomeric DNA at 2.0Å. PDB accession code 1JRN

CONFERENCE PUBLICATIONS
1. Haider, S., Ashcroft, F.M.A. and Sansom, M.S.P. (2004).
    Modelling and Simulation Studies of the Intracellular Domains of the Inwardly Rectifying K+ Channels.
    Currents in Computational Molecular Biology: 396- 398

2. Haider, S.M.S., Read, M., Reszka, J., Harrison, J., Gowan, S., Neidle, S., and Kelland, L. (2001).
    Computer-design modelling of acridones as G-Quadruplex mediated telomerase inhibitors with low cytotoxicity.
    Proceedings of the AACR- NCI - EORTC International Conference, 142

3. Haider, S.M.S., Westhead, D.R., Davies, L.A., Hopkins, P.M., Boyett, M.R. & Harrison, S.M. (2000).
    Inhibitory action of halothane on the transient outward K+ channel: Potential sites of interaction with the protein.
    Biophysical Journal 78, 221A

PROJECTS & POSTER PRESENTATIONS
1. Modelling a nd Simulation Studies of the Inwardly Rectifying KATP channel Kir6.2 subunit
    Presented at the Biophysical Society 49th Annual Meeting , Feb 12 -16, 2005, Long Beach, USA.

2. Investigating Open Pore Structure: Essential Dynamics Sampling of Motions Performed by the Inner M2 helix Bundle in
    KirBac1.1
    Presented at the Biophysical Society 49th Annual Meeting , Feb 12 -16, 2005, Long Beach, USA.

3. Modelling and Simulation studies of the Intracellular Domains of the Inwardly Rectifying K+ Channels.
    Presented at the Configurational Energy Landscapes and Structural Transitions in Clusters, Fluids and
    Biomolecules Meeting , Apr 19 Apr 21, 2004, The Royal Society, London, UK.

4. Modelling and Simulation studies of the Intracellular Domains of the Inwardly Rectifying K+ Channels.
    Presented at the RECOMB 2004 meeting, Mar 27 Mar 31, 2004, San Diego, USA.

5. Structural studies and drug -design based on G- Quadruplex DNA motif.
    Presented at the Institute of Cancer Research Conference, Jun 25- 26, 2002, Guildford, UK.
    Awarded Runner-up prize for the presentation.

6. Computer-design modelling of acridones as G-Quadruplex mediated telomerase inhibitors with low cytotoxicity.
    Presented at the Molecular Targets and Cancer therapeutics: Discovery, Biology and Clinical Applications AACR- NCI-
    EORTC International Conference, Oct 29 Nov 2, 2001, Miami, USA

7. Inhibitory action of halothane on the transient outward K channel: Potential sites of interaction with the protein.
    Presented at the Biophysical Society 44 Annual Meeting , Feb 12 -16, 2000, New Orleans, USA.