Dr. Mickael Lelimousin

Molecular dynamics simulation studies of carbon nanotube / cell membrane interactions

Research

Carbon nanotubes have potential benefits in many areas of our future life, including medicine for targeted drug-delivery. Beside promising applications, these nanoparticles may be significantly toxic for living organisms. I investigate the interactions between carbon nanotubes and cell membranes, by coarse-grained molecular dynamics simulations. I am particularly interested in the evolution of these interactions according to the size of the nanotubes.

This work is supported by the Wellcome Trust.

Publications

Membrane perturbation by carbon nanotube insertion: pathways to internalization.
Lelimousin M & Sansom MSP
Small. 2013, doi:10.1002/smll.201202640

Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%.
Goedhart J*, von Stetten D*, Noirclerc-Savoye M, Lelimousin M, Joosen L, Hink MA, van Weeren L, Gadella TWJ & Royant A
Nat. Commun. 2012, 3:751. doi:10.1038/ncomms1738

Rational design of photoconvertible and biphotochromic fluorescent proteins for advanced microscopy applications.
Adam V*, Moeyaert B*, David CC, Mizuno H, Lelimousin M, Dedecker P, Ando R, Miyawaki A, Michiels J, Engelborghs Y, & Hofkens J
Chem. Biol. 2011, 18(10):1241-51. http://dx.doi.org/10.1016/j.chembiol.2011.08.007

Structural basis of x-ray induced transient photobleaching in a photoactivatable green fluorescent protein.
Adam V, Carpentier P, Violot S, Lelimousin M, Darnault C, Nienhaus GU & Bourgeois D
J. Am. Chem. Soc. 2009, 131(50):18063-5. doi:10.1021/ja907296v

Photoconversion of the fluorescent protein EosFP: a hybrid potential simulation study reveals intersystem crossings.
Lelimousin M, Adam V, Nienhaus GU, Bourgeois D & Field MJ
J. Am. Chem. Soc. 2009, 131(46):16814-23. doi:10.1021/ja905380y

Intrinsic dynamics in ECFP and Cerulean control fluorescence quantum yield.
Lelimousin M*, Noirclerc-Savoye M*, Lazareno-Saez C*, Paetzold B, Le Vot S, Chazal R, Macheboeuf P, Field MJ, Bourgeois D & Royant A
Biochemistry 2009, 48(42):10038-46. doi:10.1021/bi901093w

Structural characterization of IrisFP, an optical highlighter undergoing multiple photo-induced transformations.
Adam V, Lelimousin M, Boehme S, Desfonds G, Nienhaus K, Field MJ, Wiedenmann J, McSweeney S, Nienhaus GU & Bourgeois D
Proc. Nat. Acad. Sci. U.S.A. 2008, 105(47):18343-8. doi:10.1073/pnas.0805949105

* joint first authors

PhD Thesis

Traitement des interactions électrostatiques dans les systèmes moléculaires - Etude par simulation numérique de protéines fluorescentes.
Lelimousin M, 2009, oai:tel.archives-ouvertes.fr:tel-00446463