Oxford University, Structural Bioinformatics & Computational Biochemistry Unit
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Dr Antreas C. Kalli

Structural Bioinformatics and Computational Biochemistry Unit
Dept. of Biochemistry
University of Oxford
South Parks Road

Telephone: 01865 613304
Fax: 01865 613238

e-mail: antreas.kalli@bioch.ox.ac.uk

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Investigation of membrane and peripheral proteins involved in signal transduction


My research is focused on the investigation of biologically significant membrane and peripheral proteins involved in signal transduction pathways with the use of computational and experimental approaches

My research is funded by the Wellcome Trust.


Kalli, A.C., et al., The Structure of the Talin/Integrin Complex at a Lipid Bilayer: An NMR and MD Simulation Study. Structure, 2010. 18(10): p. 1280-1288.

Kalli, A.C., I.D. Campbell, and M.S.P. Sansom, Multiscale simulations suggest a mechanism for integrin inside-out activation. Proceedings of the National Academy of Sciences, 2011. 108(29): p. 11890-11895.

Kalli, A.C., et al., A Helix Heterodimer in a Lipid Bilayer: Prediction of the Structure of an Integrin Transmembrane Domain via Multiscale Simulations. Structure, 2011. 19(10): p. 1477-1484.

Kalli, A.C., et al., Interactions of the Auxilin-1 PTEN-like Domain with Model Membranes Result in nanoclustering of Phosphatidyl Inositol Phosphates. Biophysical Journal, 2013 105(1):137-145.

Kalli, A.C., I.D. Campbell and M.S.P. Sansom, Conformational Changes in Talin on Binding to Anionic Phospholipid Membranes Facilitate Signalling by Integrin Transmembrane Helices. PLOS Comput. Biol., 2013 9(10):e1003316.

Kalli, A.C., et al., Interactions of PTEN Proteins with Phosphatidyl Inositol Phosphates: Insights from Molecular Dynamics Simulations of PTEN and VSP. Biochemistry, 2014. 53(11), 1724-1732.

Kalli, A.C., and M.S.P. Sansom, Interactions of Peripheral Proteins with Model Membranes as Viewed by Molecular Dynamics Simulations. Biochem. Soc. Trans., 2014 (42), 1418-1424

Last updated 29/10/07