SBCB Unit: G. Benjamin Morris
Oxford University, Structural Bioinformatics & Computational Biochemistry Unit
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G. Benjamin Morris

Structural Bioinformatics and Computational Biochemistry Unit
Dept. of Biochemistry
University of Oxford
South Parks Road

Telephone: 01865 613304
Fax: 01865 613238


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Computational Drug Design in G-Protein Coupled Receptors. A Hierarchical Approach.

Due to the lack of availability of GPCR structures, there is a need for high quality GPCR modelling to guide medicinal chemistry. My work is in collaboration with Evotec who have developed a GPCR modelling platform. My work focuses on improving various aspects of this platform, and using that in conjunction with simulation methodologies, to rationalize drug-development against several drug targets.
I work closely with Dr. Alexander Heifetz who is a Royal Society Industry Fellow, and a Principal Scientist in the computational group of Evotec.

My research is funded by the BBSRC and Evotec in the form of a CASE studentship.


I completed a BSc in chemistry at the University of Bristol in 2011. For my undergraduate research project in my final year I worked with Dr. Christopher Woods, in the Mulholland Group, using MC and MD methods to calculate absolute binding free energies.

I joined the Biggin Group in October 2011 as a DPhil student. I am a graduate student at Lady Margaret Hall.


  1. Study of Human Orexin-1 and -2 G-Protein-Coupled Receptors with Novel and Published Antagonists by Modeling, Molecular Dynamics Simulations, and Site-Directed Mutagenesis.
    Heifetz, A., Morris, G.B., Biggin, P.C., Barker, O., Fryatt, T. Bentley, J., Hallett, D., Manikowski, D., Pal, S. , Reifegerste, R., Slack, M. and Law R.
    Biochemistry (2012) (PMID: 22448975)

Last updated 6th April 2012