Azizah Mohd Asi

Homology modelling and simulations of the Major Facilitator Superfamily transporters

Research

I'm a DPhil student working under Prof Mark Sansom and Dr Phil Biggin supervision.

I work on homology model assessment of the Major Facilitator SuperFamily (MFS) transporters using data from MD simulations. Current tools developed on structure model assessment are mainly based on statistical analysis on data archived in the PDB and the use of crystal structures' parameters. This may lead to bias in conformational assessment as model generation methods (generally) rely on parameters from crystal structures. My focus in this study would be to design an analysis in homology model assessment on a different measure, ie. MD which uses a molecular-mechanics based force field, which would be free from constraints imposed by crystal structures' parameters. This work involves bioinformatics, techniques of data-filtering and statistical calculations

I did both BSc and MSc in the University of Malaya, Kuala Lumpur, Malaysia.