Santiago Manrique Zuniga


Structural Bioinformatics and Computational Biochemistry Unit
Dept. of Biochemistry
University of Oxford
South Parks Road
Oxford
OX1 3QU
U.K.

Telephone: 01865 613304
Fax: 01865 613238

e-mail: santiago@strubi.ox.ac.uk
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MD Simulation Studies of FGFR family RTKs


Background


I completed a BSc (2009) and a MSc (2011) in Biochemistry at Ruhr-University Bochum (Germany), University College London (UK) and the Max Planck Institute for Molecular Physiology (Germany).

My PhD training was in Structural Biology from University of Oxford (Lady Margaret Hall), supervised by Prof Mark S.P. Sansom and Prof E. Yvonne Jones, funded by the Henry Wellcome Trust Structural Biology DPhil Programme. My research was focused on the computational and structural analysis of Fibroblast Growth Factor Receptor signalling complex formation.


Research


The current focus of my postdoctoral research is on the formation of different signalling complex architectures in receptor clustering by analysis of dimerisation processes of full-length FGF receptor in live cells upon ligand activation.


Publications


Reddy T, Manrique S, Buyan A, Hall B, Chetwynd A, and Sansom MSP
Primary and Secondary Dimer Interfaces of the Fibroblast Growth Factor Receptor 3 Transmembrane Domain: Characterization via Multiscale Molecular Dynamics Simulations
Biochemistry. 2014

Mangino G, Percario ZA, Fiorucci G, Vaccari G, Acconcia F, Chiarabelli C, Leone S, Noto A, Horenkamp FA, Manrique S, Romeo G, Polticelli F, Geyer M, Affabris E
HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.
PLoS One. 2011;6(8):e22982

Mangino G, Percario ZA, Fiorucci G, Vaccari G, Acconcia F, Chiarabelli C, Leone S, Noto A, Horenkamp FA, Manrique S, Romeo G, Polticelli F, Geyer M, Affabris E
The conserved acidic cluster domain of HIV1 Nef is required to induces a proinflammatory state in primary macrophages: involvement of TNF alpha receptor associated factor 2.
Cytokine. 2011;56(1):28-28

Mangino G, Percario ZA, Fiorucci G, Vaccari G, Manrique S, Romeo G, Federico M, Geyer M, Affabris E
In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the release of beta interferon.
J Virol. 2007 Mar;81(6):2777-91
Last updated 09/01/14