SBCB Unit: Joanna M Lee
Oxford University, Structural Bioinformatics & Computational Biochemistry Unit
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Joanna M Lee

Structural Bioinformatics and Computational Biochemistry Unit
Dept. of Biochemistry
University of Oxford
South Parks Road

Telephone: 01865 613304
Fax: 01865 613238


division line

Modeling and molecular dynamic studies of the racetam drug target SV2A


Levetiracetam has been effectively administered as an anticonvsulsant drug under the trade name Keppra. However very little is known about it's target including the native ligand of this protein. The target protein (SV2A) is a membrane protein which sits within the synaptic vesicle membrane and homology studies have shown that SV2A has sequence similarities to MFS transporters. There is no determined structure for SV2A, therefore I am using molecular dynamics in order to build a model of the protein and better understand the protein's structural features. This project is supervised by Dr. Phil Biggin and Florence Lebon at UCB.

My research is funded by the BBSRC and UCB in the form of a CASE studentship.


I completed an undergraduate MChem in Chemistry with Industrial Experience at the University of Edinburgh in June 2011. This degree entailed a year working at the Unilever R&D department at Colworth, Bedfordshire.

In October 2011 I became a graduate student at Lady Margaret Hall, also joining the Biggin Group as a DPhil student.


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Last updated 16th March 2012