Antreas C. Kalli

Investigation of the integrin inside-out activation mechanism

Research

My research is focused on the investigation of integrin properties using coarse-grained and atomistic molecular dynamics simulations. Integrins are cell surface receptors which are involved in many cellular processes such as cell migration, cell adhesion differentiation, proliferation, apoptosis and signal transduction. I am currently interested in aIIbbeta3 activation mechanism.

My research is funded by the Wellcome Trust.

Publications

Kalli, A.C., et al., The Structure of the Talin/Integrin Complex at a Lipid Bilayer: An NMR and MD Simulation Study. Structure, 2010. 18(10): p. 1280-1288.

Kalli, A.C., I.D. Campbell, and M.S.P. Sansom, Multiscale simulations suggest a mechanism for integrin inside-out activation. Proceedings of the National Academy of Sciences, 2011. 108(29): p. 11890-11895.

Kalli, A.C., et al., A Helix Heterodimer in a Lipid Bilayer: Prediction of the Structure of an Integrin Transmembrane Domain via Multiscale Simulations. Structure, 2011. 19(10): p. 1477-1484.

Kalli, A.C., et al., Interactions of the Auxilin-1 PTEN-like domain with model membranes result in nanoclustering of phosphatidyl inisitol phospahtes. Biophysical journal, 2013. In press.