George Hedger


Structural Bioinformatics and Computational Biochemistry Unit
Dept. of Biochemistry
University of Oxford
South Parks Road
Oxford
OX1 3QU
U.K.

Telephone: 01865 613304
Fax: 01865 613238

e-mail: george.hedger@lincoln.ox.ac.uk

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Characterising lipid-protein interactions through computational modelling


Background

I obtained my undergraduate degree in Biochemistry from the University of Oxford in 2014. My final year masters project involved investigating lipid interactions of the human receptor tyrosine kinase (hRTK) family of membrane proteins, and was supervised by Dr Heidi Koldsø.

My DPhil is co-supervised by Prof Mark Sansom and Dr Heidi Koldsø. I am funded by a scholarship from the MRC and the Department of Biochemistry.


Research

My research involves application of molecular dynamics to probe the lipid interactions of biomedically important membrane proteins. The current focus of my research is on the interactions of the epidermal growth factor receptor (EGFR) and the Insulin receptor (IR) with the modulatory glycolipid GM3 and the phosphoinositide PIP2 at the plasma membrane. Additionally, I am working on projects examining cardiolipin interactions with the ADP/ATP carrier (AAC1/ANT) within the inner membrane of mitochondria.


Publications

Google Scholar Profile

Hedger, G.; Shorthouse, D.; Koldsø, H.; Sansom, M. S. P. (2016) Free energy landscape of lipid interactions with regulatory binding sites on the transmembrane domain of the EGF receptor.
Journal of Physical Chemistry B, doi:10.1021/acs.jpcb.6b01387 Link

Hedger, G.; Sansom, M. S. P. (2016) Lipid interaction sites on channels, transporters and receptors: Recent insights from molecular dynamics simulations.
Biochimica et Biophysica Acta - Biomembranes, 1858, 2390-2400, doi:10.1016/j.bbamem.2016.02.037 Link

Byrne, E. F. X.; Sircar, R.; Miller, P. S.; Hedger, G.; Luchetti, G.; Nachtergaele, S.; Tully, M. D.; Mydock-McGrane, L.; Covey, D. F.; Rambo, R. P.; Sansom, M. S. P.; Newstead, S.; Rohatgi, R.; Siebold, C. (2016) Structural basis of smoothened regulation by its extracellular domains.
Nature, 535, 517-522, doi:10.1038/nature18934 Link

Shorthouse, D.; Hedger, G.; Koldsø, H.; Sansom, M. S. P. (2016) Molecular simulations of glycolipids: Towards mammalian cell membrane models.
Biochimie, 120, 105-109, doi:10.1016/j.biochi.2015.09.033 Link

Hedger, G.; Sansom, M. S. P.; Koldsø, H. (2015) The juxtamembrane regions of human receptor tyrosine kinases exhibit conserved interaction sites with anionic lipids.
Scientific Reports, 5, 9198, doi:10.1038/srep09198 Link

Last updated &&/&&/07